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Future of Endpoints
Session Chair(s)
Bill Byrom, PHD
Vice President, Product Intelligence and Positioning; Principal, eCOA Science
Signant Health , United Kingdom
In this session, we review the use of mobile and sensor technology and its application in clinical research. Considering a 2000 subject case study, we appraise the use of mobile solutions to collect field-based patient-reported outcomes and patient engagement in a one year clinical trial. We look to the capabilities of modern technology solutions in leveraging the measurement of new health outcomes and trial endpoints. Considering the technology inherent in gaming platforms we appraise its capability to measure objective performance outcomes in non-specialist clinic settings. Finally, we explore app-based performance tests leveraging in-built smartphone sensors to provide frequent measures of aspects of symptomatology in Parkinson’s disease from the home setting. We consider how these approaches may lead to robust future endpoints to inform drug development and regulatory submissions.
Learning Objective : Describe the benefits and challenges of electronic collection of patient-reported outcomes data with reference to a mega trial; Discuss the potential of motion-based gaming platforms to collect novel movement-based endpoints; Appraise the potential of smartphone sensors in measurement and development of new digital endpoints.
Speaker(s)
New Ways to Objectively Measure Pain
Alejandro Zamorano, MS
PainQx, United States
Vice President, Business Development
Game On: Leveraging Video Game Platforms to Measure Clinical Endpoints
Bill Byrom, PHD
Signant Health , United Kingdom
Vice President, Product Intelligence and Positioning; Principal, eCOA Science
Digital Biomarkers: Towards Modernized Endpoints
Christian Gossens, PHD
F. Hoffmann-La Roche Ltd., Switzerland
Global Area Head, Digital Biomarker Informatics