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W 36: The Influence of Atipic Antipsychotic Drugs on Vas Deferens in Mice
Associate Professor, Department of Medical Pharmacology
Sakarya University Turkey
Beside dopamine, serotonine is the second important neurotransmitter to influence sexual dysfunction. Serotonin mainly inhibits sexual function by stimulating postsinaptic 5-HT2A and 5-HT2C receptors. Implications for future research; atipic antipsychotics should be strongly taken into account.
Male mice were treated by ip injection of drugs during 21 days. Then, the effects of saline, quetiapine (5 and 10 mg/kg), olanzapine (1 and 2 mg/kg) and risperidone (0.25 and 0.5 mg/kg) were investigated on serotonin and KCl-induced contractile responses in isolated vas deferens strips.
Serotonin-induced contractile responses were significantly increased in the epididymal and prostatic portion of the vas deferens obtained from the risperidone-treated group. The Emax value for serotonin was significantly higher in prostatic and epididymal portions of the mice vas deferens obtained from risperidone-treated group than control group. However, olanzapine and quetiapine treatment had no effect on serotonin responses in both epipdidymal and prostatic portions of mice vas deferens. There were no significant differences in KCl-induced contractile responses among the groups.
Risperidone but not olanzapine and quetiapine could impair sexual competence in male mice. Serotonergic purinergic receptors may, at least in part, contribute to changes in vas deferens contractions in mice with chronic treatment of risperidone but not olanzapine and quetiapine. This study will help clinicians make a purpose-oriented choice of which antipsychotic drug to use.