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The Pennsylvania Convention Center

Jun 14, 2026 7:00 AM - Jun 18, 2026 3:00 PM

1101 Arch Street, Philadelphia, PA 19107, USA

DIA 2026 Global Annual Meeting

Modernizing Nonclinical Safety Assessment: FDA and EMA Roadmaps to Reduce Animal Testing

Session Chair(s)

Imein  Bousnina, PHARMD, MSC

Imein Bousnina, PHARMD, MSC

Director, US Regulatory Policy, Product Development Regulatory

Genentech, A Member of the Roche Group, United States

This session explores the FDA and EMA’s evolving strategies to modernize nonclinical regulatory frameworks. We will examine both agency initiatives to reduce animal testing where scientifically appropriate and their roadmaps for increasing the regulatory acceptance of New Approach Methodologies (NAMs). We will discuss efforts to drive international harmonization on alternative nonclinical strategies via ICH. Participants will also gain insights into how the industry is currently integrating NAMs into submissions and broader strategies for animal testing reduction.

Learning Objective : Describe FDA's objectives under their roadmap to reducing animal testing in preclinical safety studies; Recognize EMA's ongoing activities to promote the integration of NAMs and reduce NHP studies; Discuss international harmonization via ICH; Discuss industry's experience to date with submitting NAMs in regulatory applications and overall reduction of animal testing strategies.

Speaker(s)

Amanda  Roache, MS

Modernizing Nonclinical Safety Assessment via ICH

Amanda Roache, MS

PhRMA, United States

Deputy Vice President, Science and Regulatory Advocacy

Haleh  Saber, PHD

FDA Presentation on Modernizing Nonclinical Safety Assessment

Haleh Saber, PHD

FDA, United States

Deputy Director, DHOT/ OHOP/ CDER

Orla  Moriarty, PHD

EMA Presentation on Modernizing Nonclinical Safety Assessment

Orla Moriarty, PHD

European Medicines Agency, Netherlands

Scientific Officer

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