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DIA 2018 Global Annual Meeting

The DIA 2018 Global Annual Meeting brings together thousands of innovators from around the globe.


Development of Microbiome-Derived Therapeutics

    Session Chair(s)
      Philip  Brooks, PhD

      Philip Brooks, PhD

      • Program Director, Office of Rare Diseases Research & Div of Clinical Innovation
      • NIH, National Center for Advancing Translational Sciences (NCATS), United States
    In addition to human cells, our bodies contain an even greater number of microbial cells, collectively referred to as the human microbiome. The majority of these reside in the gastrointestinal tract. Over the past several years, it has become clear that the microbiome within the human body impacts and regulates not only the function of the gut, but also many aspects of clinically relevant biology, including the immune system, liver, and brain, and can also influence carcinogenesis. Approaches to drug development involving modulating the function of the microbiome include both small molecules (e.g. probiotics), as well as the direct transfer of microbial cells. This session will highlight some of the current approaches to targeting the microbiome using cell transfer, as well as a discussion of the regulatory landscape for microbiome targeted drug development.to be developed.
    Learning Objective : Illustrate two approaches to modulating microbiome function; Describe the medical, regulatory, and operational challenges to microbiome targeted therapies.
    Speaker(s)
      Taruna  Khurana, PhD, MS

      FDA Perspective

      Taruna Khurana, PhD, MS

      • Regulatory Biologist, OVRR, CBER
      • FDA, United States
      Aoife  Brennan

      Applying Principles of Rational Drug Development to Living Medicines

      Aoife Brennan

      • Chief Medical Officer
      • Synlogic, United States
      Zain  Kassam, MD, MPH

      The Next Generation of Clinical Trials: Lessons from the Hurdles of the Microbiome

      Zain Kassam, MD, MPH

      • Executive Vice President, Clinical Development and Translational Medicine
      • Finch Therapeutics Group, United States