Become a member

Cart (0)

Already a DIA Member? Sign in. Not a member? Join.

Sign in

Forgot User ID? or Forgot Password?

Not a Member?

Create Account and Join

DIA Global Center

Nov 09, 2017 8:15 AM - Nov 10, 2017 3:30 PM

21 Dupont Circle NW, Suite 300, Washington, DC 20036

Adaptive Design in Clinical Trials: When and How to Apply

Back to Agenda

Case Study 1 and 2

Session Chair(s)

Sandeep Menon, PhD

Sandeep Menon, PhD

Chief Scientific Officer of Artificial Intelligence and Digital Science and SVP,

Pfizer Inc, United States

Case Study 1
An exploratory two-stage frequentist adaptive design (Maximizing design)

Stage 1 is the Proof of Concept phase and Stage 2 the dose-finding phase

Case Study 2
An exploratory two-stage Bayesian adaptive design (NDLM design using SPCD approach)

Adaptations are made at the end of Stage 1 and throughout Stage 2 based on a NDLM design with PoC and DF both based on a combined analysis of Treatment Periods 1 and 2 using a SPCD approach

Have an account?