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Bethesda North Marriott Hotel and Conference Center

Apr 25, 2022 7:00 AM - Apr 27, 2022 12:00 PM

5701 Marinelli Road, , North Bethesda, MD 20852 , USA

DIA/FDA Oligonucleotide-Based Therapeutics Conference

DIA Your Way! Join us live in-person or live from the comfort of your home/office. This event offers two learning avenues depending on your preference!

Session 10 Track 1 and 2 – Alternative Approaches to Other Extrahepatic Delivery

Session Chair(s)

Andrew  Slugg, MBA, MS

Andrew Slugg, MBA, MS

Senior Vice President, Global Head of Regulatory Affairs

Alnylam Pharmaceuticals, United States

Elena  Braithwaite, PhD

Elena Braithwaite, PhD


FDA, United States

Targeted delivery of oligonucleotide-based therapeutics allows for the possibility of unlocking previously inaccessible targets, enhancing target engagement leading to increased therapeutic outcomes with reduced doses and the potential for fewer off-target effects. This session will discuss a number of emerging novel targeting and delivery strategies for increasing productive uptake into a variety of cell types that normally are challenging to reach with oligonucleotide therapeutics.

Learning Objective : At the conclusion of this session, participants should be able to:
  • Identify multiple emerging novel targeting strategies for oligonucleotides
  • Discuss different strategies for targeting novel cell-types with oligonucleotides
  • Contrast the development challenges and opportunities of a variety of emerging novel targeting strategies for oligonucleotides


Arthur A. Levin, PhD


Arthur A. Levin, PhD

Avidity Biosciences , United States


Robert  MacLeod, PhD


Robert MacLeod, PhD

Flamingo Therapeutics, Belgium

Chief Scientific Officer, SVP Research and Development

Daniel J. Siegwart, PhD, MS


Daniel J. Siegwart, PhD, MS

University of Texas Southwestern Medical Center, United States

Associate Professor, Department of Biochemistry, SCCC

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