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Session 3 Track 1: Clinical Development of Oligonucleotide Therapeutics for Viral and Kidney Diseases
Session Chair(s)
Laura Sepp-Lorenzino, PhD
Chief Scientific Officer
Intellia Therapeutics, Inc., United States
Zheng Li Li, PhD
Pharmacologist
FDA, United States
This session will provide updates on siRNAs in clinical development for chronic hepatitis and cancer. Liver-targeted silencers of Hepatitis B Virus are being developed in combination with viral life cycle inhibitors and immune enhancing therapies, with the goal of breaking tolerance and establishing a functional cure in chronic hepatitis B patients. Phase ½ mono and combination therapy data for two HBV silencers will be presented. The last talk will highlight the clinical experience with an extra-hepatic siRNA candidate being developed for renal cell carcinoma, targeting HIF2.
Learning Objective : At the conclusion of this session, participants should be able to:
- Compare and contrast various oligonucleotide modalities and their applications
- Recognize clinical development considerations and trial designs for mono and combination therapies
- Discuss data from most advanced oligonucleotide drug/candidates for liver and kidney disease targets
Speaker(s)
Clinical Development of VIR-2218, a GalNAc-siRNA Targeting Hepatitis B, in Combination with Immune Enhancing Therapies
Daniel Cloutier, PharmD
Vir Biotechnology, Inc., United States
Senior Director, Clinical Research, Clinical Lead, HBV Program
Short Interfering RNA JNJ-3989 Combination Therapy
Michael Biermer, MD
Janssen Pharmaceuticals, Belgium
Senior Medical Director, Clinical Development
ARO-HIF2 for Treatment of Clear Cell Renal Cell Carcinoma Ph1b
James Hamilton Hamilton, MD, MBA
Arrowhead Pharmaceuticals, United States
Senior Vice President, Discovery and Transitional Medicine
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