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Virtual

31 mar 2026 1:00 p.m. - 31 mar 2026 2:00 p.m.

(US Eastern Standard Time)

How Will We Know They Work? Challenges in Evaluating Multicancer Detection Tests

Clinical trials evaluating multicancer detection tests should measure benefits as well as harms, including possible overdiagnosis and longer wait times for follow-up care.

Presenters

Sean  Mann, MSC

Sean Mann, MSC

Policy Analyst, RAND, United States

Sean Mann is a senior policy analyst at RAND and a professor of policy analysis at the RAND School of Public Policy. His work explores critical issues in clinical trial design and the use of artificial intelligence in health care.

Rita F. Redberg, MD, MSC, FACC

Rita F. Redberg, MD, MSC, FACC

Director, Women's Cardiovascular Services; Professor of Medicine, UCSF Medical Center, United States

Dr. Redberg is a general Cardiologist and interested in preventive cardiology. Her research interests are in our use of medical procedures and devices. She studies the regulatory process for medical devices and the strength of evidence that supports them, particularly high-risk devices, both before and after they are marketed. She is a strong proponent of high-quality data to support safety and effectiveness for medical devices, in order to provide the best quality and appropriate medical care and advice. Dr Redberg has testified before Congress multiple times on these issues. Dr. Redberg served as Editor-in-Chief of JAMA Internal Medicine and on the Medicare Payment Advisory Commission, which advises Congress on medical payment policy.

Sanket  Dhruva, MD, MHS

Sanket Dhruva, MD, MHS

Associate Professor, Medicine, University of California San Francisco, United States

Dr. Dhruva is an Associate Professor of Medicine who uses health services research methods to understand and strengthen the evidence base for the safe and effective use of drugs and medical devices, with the goal of improving the quality of care and clinical outcomes for patients. One central focus is on reducing low-value care from medical devices. Dr. Dhruva has more than 250 peer-reviewed publications, including in leading academic journals such as the New England Journal of Medicine, Journal of the American Medical Association (JAMA), JAMA Internal Medicine, and BMJ.

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