15th DIA Japan Annual Meeting 2018

For realization of genomic medicine, we need to elucidate characteristics, temporal-spatial diversity and origin of cancer by using large-scale sequencing data analyses obtained from whole genome sequence, RNA sequence, and methylation sequence. The Institute of Medical Science, The University of Tokyo, aims to establish the integrated computational life science that constitutes the basis for personalized/preventive medicine. This requires a methodology for comprehensive understanding of pathological states and exploration of their effective treatments through a view from genome to the whole body, both environmentand organism-spatiotemporally. We consider that this methodology can be realized by “information technology”, “application of physics principles”, and “utilization of big data”. In this keynote lecture, the perspective on the genomic medicine and the innovation strategy for drug development will be described, from the viewpoints of the integrated computational life science.