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DIA/FDA Oligonucleotide-Based Therapeutics Conference
Session 5 Track 2: Advances in CNS Delivery of Oligonucleotides
Session Chair(s)
Jeffrey Foy, PhD
- Vice President, Toxicology
- PepGen Inc., United States

Lois M. Freed, PhD
- Director, Division of Pharmacology/Toxicology-Neuroscience (DPT-N), CDER
- FDA, United States
This session will focus on current research efforts in the area of neurological diseases. Improved oligonucleotide delivery and pharmacokinetics/interspecies scaling for neurological assessment based on age and exposure levels will be the focus of the session
Learning Objective : At the conclusion of this session, participants should be able to:
- Discuss the new areas of oligonucleotide research and potential treatments for neurological disorders
- Better understand mechanisms of CNS uptake and pharmacokinetics of oligonucleotides
- Identify nonclinical study design considerations for nonclinical studies of oligonucleotides for CNS disorders
Speaker(s)

Expanding the Reach of RNAi Therapeutics
Lan Dang, PhD
- Senior Scientist
- Alnylam Pharmaceuticals, United States

Comparison of PK Exposure Between Juvenile and Adult Animals After Intrathecal Administration
Daniel Norris, PhD, RPh
- Executive Director, Pharmacokinetics and Clinical Pharmacology
- Ionis Pharmaceuticals , United States
Overcoming the Blood–Brain Barrier for RNA Therapeutics
Branden Ryu, PhD
- Cheif Executive Officer
- BIORCHESTRA Co., Ltd., Korea, Republic of
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